Role of Streptococcus agalactiae glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in infection and potential as a target to control colonization in the female genital tract

病原细菌产生的细胞外蛋白可以通过介导与宿主细胞的结合和调节免疫系统来促进微生物在宿主的定植。这些蛋白质通过破坏免疫系统的特定元素发挥作用，从而使感染恶化。该项目将增加我们对这种细菌如何长期定殖于人类的理解，并将确定一种称为GAPDH的细菌蛋白作为控制靶标的潜力。

Extracellular proteins produced by pathogenic bacteria can facilitate microbial colonization of the host by mediating binding to host cells and by modulating the immune system. These proteins exert their effects by subverting specific elements of the immune system and this can allow infection to worsen. This project will increase our understanding of how this bacterium chronically colonizes humans and will identify the potential of a bacterial protein, termed GAPDH, as a target for control.