Role of vasoactive hormones and cytokines in diabetic nephropathy

肾脏疾病是澳大利亚人口残疾和过早死亡的主要原因。在糖尿病肾病中，高血压的存在是加速这种疾病进展的一个主要因素。事实上，国际和国家组织现在建议对糖尿病患者进行积极的血压治疗。这项建议旨在优化糖尿病的血压治疗，并评估新的更有效的降压药，这些降压药在肾脏内阻断与糖尿病肾脏疾病有关的重要激素途径。这一方法将有助于确定导致高血压引起的肾脏损害的关键因素。预计这些研究将导致更合理、更有针对性和更有效的降压药物，从而延缓或预防糖尿病肾病的发展。

Kidney disease is a major cause of disability and premature death in the Australian population. In diabetic kidney disease a major factor which accelerates the progression of this disorder is the presence of hypertension. Indeed international and national organisations now recommend aggressive blood pressure treatment in the diabetic patient. This proposal aims to optimise blood pressure treatment in diabetes and evaluate novel more potent blood pressure lowering agents which block within the kidney important hormonal pathways implicated in diabetic kidney disease. This approach will assist in determining key factors which mediate the damage to the kidney induced by elevated blood pressure. It is anticipated that these studies will lead to more rational, targeted and powerful antihypertensive agents which will retard or prevent the development of diabetic nephropathy.