Roles of the nuclear growth hormone receptor in cell proliferation and survival

我们已经发现，生长激素的细胞表面受体在细胞分裂过程中进入细胞核，包括癌细胞。考虑到生长激素在出生后促进生长的作用，我们试图揭示核受体是如何直接和通过基因拼接促进增殖的。我们已经通过蛋白质组学和受体的DNA结合位点确定了其直接作用的强有力的候选者。在这里，我们将研究它在细胞辐射后的增殖、基因剪接和DNA链断裂修复中的作用。

We have discovered that the cell surface receptor for growth hormone travels to the cell nucleus in dividing cells, including cancer cells. Given the role of growth hormone in promoting growth postnatally, we seek to uncover how the nuclear receptor promotes proliferation directly, and by gene splicing. We have identified strong candidates for its direct actions through proteomics, and a DNA binding site for the receptor. Here we will investigate its role in proliferation, gene splicing and DNA strand break repair after cell irradiation.