Influence of nutrition and physical activity on skeletal muscle membrane structure and function

包围着我们体内每个细胞的生物膜是重要的选择性渗透屏障，执行与细胞生长、通讯和新陈代谢相关的许多关键细胞过程。膜结构在一定程度上取决于其脂肪酸组成。膜结构的变化会影响细胞功能。这项研究的主要重点是通过检测特定骨骼肌细胞器的脂肪酸组成，研究饮食(高脂肪)和运动(耐力训练)对膜结构的影响。具体地说，这项建议解决了不同种类的膳食脂肪(饱和、单不饱和和多不饱和脂肪)的意义及其在膜重构中的作用。该研究计划的长期目标是比较和对比健康哺乳动物骨骼肌潜在的生理和代谢适应与营养和体力活动，以及在某些代谢疾病(如肥胖症和2型糖尿病)下这些适应的差异。

Biological membranes that surround every cell in our body are important selectively permeable barriers that carry out many critical cellular processes associated with cell growth, communication, and metabolism.  Membrane structure is dependent, in part, on its fatty acid composition.  Alterations to membrane structure can impact cellular function. The major focus of the proposed research is to examine how membrane structure is influenced with diet (high fat) and exercise (endurance training) by examining the fatty acid composition of specific skeletal muscle organelles.  Specifically, this proposal addressed the significance of different kinds of dietary fats (saturated, monounsaturated, and polyunsaturated fats) and their role in membrane remodelling.  The long-term goals of this research program are to compare and contrast the underlying physiological and metabolic adaptations in healthy mammalian skeletal muscle with nutrition and physical activity and how these adaptations differ under certain metabolic disorders such as obesity and type 2 diabetes.