Development of a Lab-on-a-Chip solution for detection of Diarrhoea Viruses: A nanotechnology empowered microdevice

生物信息学数据库的发展导致了对分析系统的需求，这些分析系统能够处理非常小的样本，但仍然能够提供关于样本中所含特定生物分子的信息。在过去的十年中，用于这些目的的生物样本的处理是自动化的、小规模的、高通量的操作，成本较低，但不会影响精度。将生物医学设备微型化到微米量级的能力创造了一种新的范式，在此基础上进行药物开发、生物技术开发、基因分析以及临床诊断和治疗。使用微电子机械系统(MEMS)和纳米技术的芯片实验室设备的发展使多个分子诊断系统的小型化和集成化成为可能。拟议的项目将专注于开发一种芯片上实验室设备，以执行多种功能，如芯片上细胞分离、细胞裂解、生物分子分离和实时聚合酶链式反应。所开发的设备或子系统被设想集成在水和废物处理设施中，以实时监测病原体。

The development of bioinformatics databases has led to the demand for analytical systems capable of handling very small samples but still being able to provide information on specific biomolecules contained within the samples. During the past decade, processing of biological samples for these purposes is automated, at a small-scale, and high-throughput operation with lower cost but without compromise in accuracy. The ability to miniaturize biomedical devices to the order of micrometers has created a new paradigm based on which drug development, biotechnology development, genetic analysis, and clinical diagnosis and treatment are performed The development of Lab-on-a-Chip devices using microelectromechaical systems (MEMS) and nanotechnology has enabled the miniaturization and integration of multiple molecular diagnostic systems. The proposed project will focus on the development of a Lab-on-a-Chip device to perform multiple functions, such as on-chip cell separation, cell lysis, biomolecular separation and real-time PCR. The developed devices or subsystems are envisioned to be integrated within water and waste treatment facilities for real-time monitoring of pathogens.