Strategies for healthy osteocytes

骨细胞(Oy)是骨组织中含量最丰富的细胞类型，其高密度和高活性对于健康的骨是必不可少的。我们发现维生素K、维生素D和锶促进人类Oy分化。我们将在人类Oy分化和存活的新模型中，以及与维生素D缺乏、更年期和糖皮质激素治疗相关的骨丢失的动物模型中测试这些方法。我们的工作将有助于更好地了解人类OY，并为治疗骨质疏松症提供新的途径。

Osteocytes (OY) are the most abundant cell type in bone whose high density and viability are essential for healthy bone. We have found that vitamin K, vitamin D and strontium, promote human OY differentiation. We will test these in novel models of human OY differentiation and survival, and in animal models of bone loss associated with vitamin D deficiency, menopause and glucocorticoid treatment. Our work will lead to a better understanding of human OY and give a new approach to treat osteoporosis.