Studies into Myeloperoxidase-Induced Cardiovascular Disease and its Treatment

在心血管疾病期间，一种名为髓过氧化物酶(MPO)的炎性蛋白会异常释放到循环血液中，并被输送到患病的血管中。我们的研究首次表明，循环中MPO水平的增加会促进动脉粥样硬化和主动脉瘤的发生。该项目将研究MPO如何促进炎性动脉疾病，并测试新药抑制这种破坏性蛋白和预防心血管疾病的能力。

During cardiovascular disease an inflammatory protein called myeloperoxidase (MPO) becomes abnormally released into the circulating blood and is transported into diseased blood vessels. Our studies show for the first time that increasing circulating levels of MPO promotes both atherosclerosis and aortic aneurysm. This project will study how MPO promotes inflammatory artery disease and test new drugs for their ability to inhibit this damaging protein and protect against cardiovascular disease.