Translating molecular insights in Squamous Cell Carcinoma into novel therapeutics

在澳大利亚，皮肤癌占所有新发癌症病例的80%，其中超过95%是基底细胞癌(BCC)或鳞状细胞癌(SCC)。虽然暴露在阳光下是导致这两种癌症的主要因素，但目前尚不清楚是什么基因受到了破坏，使它们能够以不受控制的方式生长。我们的实验室已经确定了在鳞状细胞癌中发生故障的关键基因。这一发现将使我们能够为鳞状细胞癌开发新的预防和治疗策略。

In Australia, skin cancers account for 80% of all new cases of cancer, and over 95% of these are basal cell cancers (BCC) or squamous cell cancers (SCC). Although exposure to the sun is the major factor responsible for both of these cancers, it is not known what genes are damaged allowing them to grow in an uncontrolled manner. Our laboratory has identified critical genes that malfunction in SCC. This discovery will allow us to develop new preventative and curative strategies for SCC.