Self assembling and targeting smart biomaterials for Dengue virus diagnostics and therapeutics

这笔赠款用于检测、预防和治疗登革热病毒感染。这种病毒是一种蚊媒病毒，感染了全球1亿人。在严重的情况下，它可以导致5%的人死亡。这种病毒的两种毒株现在也在北美流行。这项研究与一家加拿大公司(Cangene Inc.、温尼伯和多伦多)合作的目标是开发用于检测和治疗这种疾病的智能生物材料。更具体地说，将开发一种基于棉签或试纸的简单免疫分析方法，用于非侵入性检测感染者。类似的抗体也将在组织培养和登革热病毒感染的小鼠模型中用于预防和治疗感染。

This grant relates to the detection, prevention and treatment of Dengue virus infection. The virus is a mosquito borne virus that infects 100 million individuals worldwide. In its severe form it can cause death in 5% of the individuals. Two strains of this virus is now also prevalent in North America. The objectives of this research in collaboration with a Canadian company (Cangene Inc, Winnipeg and Toronto) is to develop smart biomaterials for detection and treatment of the disease. More specifically, a simple swab or dipstick based immunoassay will be developed for non-invasive detection of infected individuals. Similar antibodies are also to be tested for prevention and treatment of infection in tissue culture and mouse models of dengue viral infection.