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Understanding sphingolipid mediators of insulin resistance

Understanding sphingolipid mediators of insulin resistance
了解胰岛素抵抗的鞘脂介质
批准号:
nhmrc : 1126135
负责人:
A/Pr Anthony Don
金额:
$43.91万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31

项目摘要

项目成果

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中文摘要
翻译
鞘脂是一类在细胞内具有多种功能的脂类代谢物。众所周知,过量的脂肪积累,包括某些鞘脂,会对细胞中的胰岛素作用和葡萄糖代谢产生不利影响。在这个项目中,我们将结合多种策略来检验这一假设,即神经鞘脂脂可以被操纵来对新陈代谢产生有利的影响。
英文摘要
Sphingolipids are a class of lipid metabolites that have a variety of functions within cells. It has been known for some time that an accumulation of excess lipid, including certain sphingolipids, can adversely impact insulin action and glucose metabolism in cells. In this project we will a combination of strategies to test the hypothesis that the sphingolipid profile can be manipulated to have favourable effects on metabolism.
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Understanding sphingolipid mediators of insulin resistance
  • 批准号:
    nhmrc : GNT1126135
  • 项目类别:
    Project Grants
  • 资助金额:
    $64.34万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Anthony Don
  • 依托单位:
Restoring neuroprotective sphingosine 1-phosphate signalling in Alzheimer’s Disease
  • 批准号:
    nhmrc : 1100626
  • 项目类别:
    Project Grants
  • 资助金额:
    $59.02万
  • 财政年份:
    2016
  • 负责人:
    A/Pr Anthony Don
  • 依托单位:
Restoring neuroprotective sphingosine 1-phosphate signalling in Alzheimer’s Disease
  • 批准号:
    nhmrc : GNT1100626
  • 项目类别:
    Project Grants
  • 资助金额:
    $85.77万
  • 财政年份:
    2016
  • 负责人:
    A/Pr Anthony Don
  • 依托单位:
Altered Myelin Sphingolipid Homeostasis in Alzheimer's Disease
  • 批准号:
    nhmrc : 1024966
  • 项目类别:
    Project Grants
  • 资助金额:
    $41.98万
  • 财政年份:
    2012
  • 负责人:
    A/Pr Anthony Don
  • 依托单位:
海外基金