Upgrades for 500 MHz spectrometer to enable protein NMR spectroscopy

核磁共振（NMR）光谱学可以用来阐明重要生物分子的三维结构信息，它们的结构如何随时间变化，以及它们与其他分子（如药物）的相互作用。在多伦多大学密西沙加分校，有三位研究人员使用核磁共振波谱来研究医学上重要的生物分子。他们的研究涉及复杂大分子体系的研究，这需要大量使用高场核磁共振光谱仪。目前，UTM只有一台高场光谱仪（600兆赫）能够进行生物分子核磁共振实验。要求为计算机升级和相关软件提供资金，以使第二台高场仪器，一台500兆赫光谱仪能够进行复杂的生物分子核磁共振实验。我们还要求为不间断电源（UPS）提供资金，以防止间歇性电源故障，这可能会严重损坏仪器，并对通常需要数小时或数天的生物分子核磁共振实验产生问题，因此需要UPS。通过为蛋白质核磁共振研究配备500 MHz仪器，我们可以创建一个核磁共振中心，更好地适应核磁共振组的需求。

Nuclear magnetic resonance (NMR) spectroscopy can be used to elucidate information about the 3-dimensional structural of important biological molecules, how their structure changes in time, and their interactions with other molecules, such as drugs. At the University of Toronto Mississauga, there are three researchers who use NMR spectroscopy to study medically important biological molecules. Their studies involve studies of complex macromolecular systems, which require significant access to high field NMR spectrometers. Currently, there is only one high field spectrometer (600 MHz) at UTM capable of biomolecular NMR experiments. Funds are requested for computer upgrades and associated software to render the second high field instrument, a 500 MHz spectrometer, capable of complicated biolomecular NMR experiments. We also request funding for an uninterruptable power supply (UPS) to protect against intermittent power failures, which could severely damage the instrument and are problematic for acquiring biomolecular NMR experiments that normally take many hours or days, making a UPS necessary. By equipping the 500 MHz instrument for protein NMR studies, we can create an NMR center that better accommodates the needs of the NMR groups.