A conceptually new microwave applicator
A conceptually new microwave applicator
批准号:
390674-2010
负责人:
Organ, Michael
金额:
$10.93万
依托单位:
依托单位国家:
加拿大
项目类别:
Research Tools and Instruments - Category 1 (<$150,000)
财政年份:
2009
资助国家:
加拿大
项目状态:
已结题
起止时间:
2009-01-01 至 2010-12-31
中文摘要
这项提议是为了获得一种概念上全新的微波喷头,用于微波辅助连续流动有机合成(MACOS),这是多伦多约克大学Michael G.Organ实验室开发的一项全新技术。施加器将允许照射流经窄管的化学反应,理论上,细管的长度可以是完成正在进行的转化所需的任何长度。由Organ与著名材料科学家威廉·J·皮特罗(William J.Pietro)共同开发的管子内衬着微波吸收材料,起到了天线的作用,将能量传输到反应中。在某些情况下,这导致反应时间从几天缩短到几秒钟左右!早期的MACOS系统正在其他大学(例如堪萨斯大学)和主要制药公司(例如默克制药公司)进行Beta测试。有了新设计的微波辐射器,MACOS系统将很快进入适合工程设计成商业可用系统的阶段,该系统将在加拿大制造,供世界各地使用。
英文摘要
The proposal is to attain a conceptually-new microwave applicator for use in Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS), a brand new technology developed in the laboratory of Michael G. Organ at York University in Toronto. The applicator will allow the irradiation of chemical reactions that are flowed through narrow diameter tubes that, in theory, can be of any length necessary to complete the transformation that is being conducted. The tubes being developed by Organ, in conjunction with William J. Pietro, a noted Materials Scientist, are lined with microwave-absorbing material that serve like an antenna to transmit energy to the reaction. In some cases, this has resulted in shortening reaction times literally from days to a matter of seconds! Early-stage MACOS systems are being beta tested in other universities (e.g., the University of Kansas) and in major pharmaceutical companies (e.g., Merck Pharmaceuticals). With the newly designed microwave applicator in hand, the MACOS system will soon be at a stage where it is suitable to engineer into a commercially available system that will be manufactured in Canada for use around the world.
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依托单位:
国内基金
海外基金
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