A single liquid-handling robotic platform for batch and flow chemistry applications

适用于批量和流动化学应用的单一液体处理机器人平台

• 批准号: 522115-2017
• 负责人: Organ, Michael
• 金额: $ 1.82万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=640172
• 关键词: single; liquid; handling; robotic; platform

The project will involve the design, construction and integration of reactor modules which are capable ofreceiving fluids from multiple reagent reservoirs for batch or flow synthetic chemistry experiments. Currentconventional manufacturing of fine chemicals uses large reaction vessels in which all the reagents are addedand the reaction stirred and heated or cooled as necessary to drive the transformations to completion. For avariety of reasons, such reactions can sometimes not reach preset specifications and this is referred to as a batchfailure. In the pharmaceutical sector, this can have catastrophic consequences for patients heavily reliant onconstant supply of the active pharmaceutical ingredient (API) that makes up their drugs. As a consequence, thepharmaceutical sector targets the production of 2.5X the actual annual requirement of API, just to ensure aconstant supply. This material is biologically active and if not used, must then be carefully decomposed, whichis not only an unnecessary cost but raises health and environmental concerns. Flow chemistry is seen as thefuture of the fine chemical manufacturing sector as the material is made constantly, but on a much smallerscale. So, it is safer, consumes less energy, and only produces the amount of API material that is required. Mostoften, reactions have been optimized in batch reactors, and then are modified to suit production in flow. Thereexists no platform to readily move between these two manufacturing technologies. This proposal seeks to fillthis gap with new robotic reactor technology that will allow for the ready movement back and forth betweenprocess optimization for batch reactions and for flow applications. This will be disruptive technology and thereare presently zero products in this marketspace.

该项目将涉及反应器模块的设计，建造和集成，这些模块能够从多个试剂库接收流体，用于批量或流动合成化学实验。目前传统的精细化学品生产使用大型反应容器，其中添加所有试剂，并根据需要搅拌和加热或冷却反应以完成转化。由于各种原因，这些反应有时不能达到预定的规格，这被称为批次失败。在制药行业，这可能对严重依赖构成其药物的活性药物成分（API）的持续供应的患者造成灾难性后果。因此，制药部门的目标是生产API实际年需求量的2.5倍，以确保稳定的供应。这种材料具有生物活性，如果不使用，必须仔细分解，这不仅是不必要的成本，而且会引起健康和环境问题。流动化学被视为精细化学品制造业的未来，因为材料是不断制造的，但规模要小得多。因此，它更安全，消耗更少的能量，并且仅产生所需的API材料量。大多数情况下，反应已经在间歇式反应器中优化，然后进行修改以适应流动生产。目前还没有一个平台可以在这两种制造技术之间轻松切换。该提案旨在填补这一空白与新的机器人反应器技术，将允许准备来回移动之间的过程优化批处理反应和流动的应用。这将是颠覆性的技术，目前在这个市场上没有产品。