Critical upgrade of a quadruple-time-of-flight mass spectrometer of the Queen's University MS facility

该提案需要资金升级已有6年历史的四极杆飞行时间质谱仪（QStar）的三个关键部件。它是女王大学质谱和蛋白质组学服务部门（MSPSU）的一部分，该部门支持女王大学化学、医学、生物化学、生物学和化学工程的研究项目。该光谱仪是皇后大学唯一能够提供高分辨率和串联质谱分析高分子量分子的仪器，包括蛋白质、多肽、聚合物和超分子化合物。光谱仪的三个关键部件，激光器，多通道板探测器和涡轮泵要么无法正常工作，要么接近其使用寿命，这对我们MSPSU设施服务的质量和能力构成了严重威胁，并且肯定会阻碍女王大学几十个研究小组和100多名研究生和博士后的研究工作。因此，要求的资金升级光谱仪的关键组件是至关重要的，以保持质量和竞争力的研究生研究和教育在化学和蛋白质组学在女王大学。

This proposal requires funding to upgrade three key components of a 6-year old Quadrupole time-of-flight (QStar) mass spectrometer. It is part of the Queen's University Mass spectrometry and Proteomics Services Unit (MSPSU) that supports the research programs in Chemistry, Medicine, Biochemistry, Biology and Chemical Engineering at Queen's. This spectrometer is the only instrument at Queen's that can provide high resolution and Tandem mass spectral analyses of high molecular weight molecules including proteins, peptides, polymers, and supramolecular compounds. The three key components of the spectrometer, Laser, multiple channel plate detector, and Turbo pumps are either not functional or near their lifetime, which poses a serious threat to the quality and capability of our MSPSU facility service and will certainly hamper the research efforts by several dozen research groups and more than 100 graduate students and postdoctoral fellows at Queen's. Therefore, the requested funding to upgrade the key components of the spectrometer is critical to maintain the quality and the competiveness of the graduate research and education in Chemistry and Proteomics at Queen's.