Utilizing Biomaterials to Improve the Differentiation & Integration of Human Stem Cell-Derived Neural Grafts in Parkinson’s Disease
Utilizing Biomaterials to Improve the Differentiation & Integration of Human Stem Cell-Derived Neural Grafts in Parkinson’s Disease
利用生物材料提高分化能力
批准号：
nhmrc : GNT1159265
负责人：
金额：
$80.65万
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2019
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2019-01-01 至 --
中文摘要
翻译
临床试验表明，将多巴胺神经元移植到帕金森病患者的大脑中可以改善症状。试验使用胎儿组织进行植入，这是不可持续的和高度可变的。这项提案将研究人类干细胞作为替代供体来源，并采用我们精心设计的支架来支持这些干细胞之前，之后，移植到疾病模型。
英文摘要
Clinical trials have shown that transplanting dopamine neurons into the brain of Parkinson's disease patients can improve symptoms. Trials used fetal tissue for implantation, which is unsustainable and highly variable. This proposal will examine human stem cells as an alternative donor source and employ our carefully engineered scaffolds to support these stem cells prior to, and following, transplantation into models of the disease.
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