Var gene diversity and naturally acquired immunity to malaria

在疟疾常见的地区，人们对这种疾病产生了自然免疫力，尽管由于许多寄生虫株的传播而非常缓慢。该项目将使用蛋白质微阵列来研究大多数菌株获得抗体的模式。这将揭示抗体是如何随着年龄的增长而获得的，以及抗体与预防疟疾症状有关。该研究旨在确定疟疾免疫的生物标志物，并可能导致新的候选疫苗。

In areas where malaria is common, people develop natural immunity to the disease albeit very slowly due to the many parasite strains that circulate. The project will use protein microarrays to investigate the patterns by which antibodies are acquired to the majority of strains. This will reveal how antibodies are acquired with age and which are associated with protection against malaria symptoms. The research aims to identify biomarkers of malaria immunity and may lead to new vaccine candidates.