The ZIC3 Heterotaxy-associated transcription factor: a new player in nuclear control of canonical Wnt signalling

人类有许多内部不对称，需要在所有个体中以一致的方式发生。不对称的例子包括我们不配对的器官（如心脏或肝脏）或不对称的成对器官（如肺）。在这个项目中，我们将使用尖端的分子胚胎学和细胞生物学技术来探索建立不对称的非凡壮举背后的机制，以便我们能够更好地帮助那些患有偏侧性疾病的个体。

Humans have many internal asymmetries that need to occur in a consistent manner across all individuals. Examples of asymmetry include our unpaired organs (like the heart or liver) or a paired organ with asymmetry (like the lungs). In this project we will use cutting edge molecular embryology and cell biology techniques to explore the mechanisms behind the remarkable feat of establishing asymmetry so we are better able to help those individuals with laterality disorders.