Localizing light in the eye for diagnostic and therapeutic applications

眼睛的视网膜包含感光细胞、神经元和血管。最近的自适应光学技术纠正了眼组织对光的光学效应，现在可以使光精确地聚焦在眼睛后部视网膜的这些结构上。因此，非常详细的图像是可能的，这将有助于诊断和了解由糖尿病引起的眼病。该应用程序有四个目标：1)开发一种具有自适应光学校正的仪器，以便在细胞水平上研究儿童和青少年眼睛中糖尿病引起的结构损伤；2)确定与糖尿病性眼病相关的最早变化是发生在神经细胞还是血管中；3)利用高分辨率仪器和光学方法局部检测正常和糖尿病视网膜和视觉系统的功能；4)评估将光精确输送到视网膜上的可行性，以便更早、更好地治疗糖尿病眼病。

The retina of the eye contains light sensitive cells, neurons and blood vessels. Recent adaptive optics technology to correct for the optical effects of eye tissue on light now enables light to be precisely focused onto these structures of the retina at the rear of the eye. As a result, very detailed images are possible, which will assist in the diagnosis and understanding of eye disease due to diabetes. This application has four objectives: 1) to develop an instrument with adaptive optical correction to allow the study of the structural damage due to diabetes at a cellular level in the eyes of children and adolescents; 2) to determine whether the earliest changes associated with diabetic eye disease occur in neural cells or in blood vessels; 3) to use the high-resolution instrument and optical methods to locally test the function of the normal and diabetic retina and visual system and 4) to assess the feasibility of precise delivery of light onto the retina for earlier and better treatment of diabetic eye disease.