Management of coldwater disease in rainbow trout

冷水病对不列颠哥伦比亚省淡水渔业协会生产的虹鳟鱼有明显的有害影响，虹鳟鱼被放养在全省约900个湖泊中。由于某些菌株的死亡率接近80%，因此手术的成本相当高。需要管理工具来减少这种影响。该项目有三个主要目标：表征引起冷水病的嗜冷黄杆菌菌株;了解对自体和口服疫苗接种的免疫反应，并确定三倍体鱼与二倍体鱼的反应如何不同;最后剖析F.使用专利技术测定嗜冷菌抗原的经口摄取量，以评估冷水病的实验性口服疫苗接种。本项目的结果将提供具体的立即适用的管理工具，以减弱冷水病的影响FFSBC，并将进一步发展的管理工具，供未来使用。

Coldwater disease has a marked deleterious impact on the Freshwater Fisheries Society of British Columbia's production of rainbow trout that are stocked into ~900 lakes across the province. With mortality of some strains approaching 80% the cost to the operation is substantial. Management tools to reduce this impact are required. This project has three major goals; to characterize the strains of Flavobacterium psychrophilum that cause coldwater disease; to understand the immune response to autogenous and to oral vaccination and to determine how triploids differ in their response from diploid fish; and finally to dissect the mechanisms of F. psychrophilum antigen per os uptake using patented technology in order to evaluate experimental oral vaccination for coldwater disease. The results of this project will provide concrete immediately applicable management tools to blunt the effect of coldwater disease for FFSBC and will further the development of management tools for future use.