Innate immunity of teleosts

硬骨鱼的先天免疫

• 批准号: RGPIN-2015-06395
• 负责人: Lumsden, John
• 金额: $ 2.04万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=591030
• 关键词: Innate; immunity; teleosts

My research program and the studies outlined in the present short-term objectives are designed to better understand innate resistance of fish to infectious disease. Aquaculture is responsible for up to half of all fish protein consumed worldwide and infectious disease is an important cause of lost production. Aquaculture is a growth industry for Canada and will continue to expand and support Canadian jobs in the future. The cost-benefit ratio (relatively low cost per unit product) for fish health requires that we identify innate markers for resistance to infectious disease to provide enhanced survival, without heavy reliance on antimicrobials or expensive products. We have used functional binding assays to identify serum proteins that bind to bacteria and virus. We have identified proteins that are highly likely relevant for resistance to specific pathogens and this research will address some of the mechanisms by which fish recognize and eliminate infectious agents. We now wish to examine specific roles of one of these proteins, intelectin, in resistance to

我的研究计划和目前短期目标中概述的研究旨在更好地了解鱼类对传染病的先天抵抗力。水产养殖占全世界鱼类蛋白消费量的一半，传染病是产量损失的重要原因。水产养殖是加拿大的一个增长型行业，未来将继续扩大和支持加拿大的就业机会。鱼类健康的成本效益比（单位产品成本相对较低）要求我们确定抗传染病的先天标记，以提高生存率，而不严重依赖抗菌剂或昂贵的产品。我们已经使用功能性结合测定来鉴定与细菌和病毒结合的血清蛋白。我们已经确定了与抵抗特定病原体高度相关的蛋白质，这项研究将解决鱼类识别和消除传染性病原体的一些机制。我们现在希望研究这些蛋白质之一，intelectin，在抵抗