Discovery Projects - Grant ID: DP210101504

探讨动力学在GPCR表型蛋白调节中的作用。生命依赖于将外界刺激转化为适当的生物反应的基本能力。这种刺激通过细胞表面蛋白（受体）传递，将这种刺激转化为细胞内信号。最大的一类细胞表面受体是G蛋白偶联受体（GPCR）家族。尽管在确定GPCR结构方面取得了进展，但关于GPCR功能和信号传导的结构基础的许多问题仍未得到解答。该项目的主要成果是提供对GPCR配体识别和激活动力学的机制洞察，以推进我们对GPCR信号转导的理解，这是所有生物体的基本生物学过程。

Probing the role of dynamics in protein modulation of GPCR phenotype . Life relies upon the fundamental ability to convert external stimuli into an appropriate biological response. Such stimuli are transmitted by cell surface proteins (receptors), which convert this stimulus into an intracellular signal. The largest group of cell surface receptors is the G protein-coupled receptor (GPCR) family. Despite advances in GPCR structure determination, many questions regarding the structural basis of GPCR function and signalling remain unanswered. The primary outcome of this project is to provide mechanistic insight into the dynamics of GPCR ligand recognition and activation to advance our understanding of GPCR signal transduction, a fundamental biological process for all living organisms.