A liquid chromatography system coupled to a single stage mass selective setector for the laboratory for the analysis of natural and synthetic environmental toxicants (LANSET)

渥太华大学自然和合成环境毒物分析实验室（LANSET）需要一种由二极管阵列检测器（DAD）和单四极杆质量选择检测器（MSD）连接的超高性能液相色谱（UHPLC）系统。L.A.N.S.E.T.是渥太华大学的一个研究和培训机构，为渥太华大学和其他地方的更广泛的研究界定期分析各种天然和合成环境毒物，目前得到NSERC的主要资源支持计划和渥太华大学的核心设施支持计划的支持。我们分析的基本要求是对分析物进行色谱分离，然后通过质量选择检测和光电二极管阵列检测进行分析。在过去的一年里，我们的HPLC-DAD-MS系统出现故障，无法修复，使20多个研究生项目处于严重危险之中。这里要求的替代系统是一个基本的研究工具，没有它这些项目就无法完成。此外，L.A.N.S.E.T.还为国内和国际上的大学和行业提供分析支持。UHPLC- DAD-MS平台将允许对天然产物和环境污染物进行大规模分析，并允许发现意想不到的代谢物和母体化合物的衍生物。

An ultra high performance liquid chromatography (UHPLC) system hyphenated to a diode array detector (DAD) and a single quadrupole mass selective detector (MSD) is requested for the Laboratory for the Analysis of Natural and Synthetic Environmental Toxicants (LANSET) at the University of Ottawa. L.A.N.S.E.T. is a research and training facility at the University of Ottawa that routinely analyzes a wide range of natural and synthetic environmental toxicants for the broader research community at the University of Ottawa and elsewhere and currently receives support from NSERC's Major Resources Support Program and the University of Ottawa's Core Facility Support Program. A basic requirement for our analysis is to conduct chromatographic separations of analytes followed by analysis by mass selective detection and photodiode array detection. This past year, our HPLC-DAD-MS system failed and is beyond repair, placing over 20 graduate student projects in serious jeopardy. The replacement system requested here is a fundamental research tool without which these projects cannot be completed. Moreover, L.A.N.S.E.T. provides analytical support to universities and industries nationally and internationally. A UHPLC- DAD-MS platform will permit broad-scale analysis of natural products and environmental pollutants and will permit discovery of unexpected metabolites and derivatives of the parent compounds.