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Evo-neuro and the evolution of fast neurotransmission

Evo-neuro and the evolution of fast neurotransmission
Evo-neuro 和快速神经传递的进化
批准号:
227828-2010
负责人:
Dent, Joseph
金额:
$1.97万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-01-01 至 2012-12-31

项目摘要

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中文摘要
翻译
动物神经系统是已知宇宙中最复杂、计算能力最强的对象。要解释这种复杂性是如何在分子水平上产生变化的,这对达尔文进化论来说是一个重大挑战。直到最近,随着多种多样的后生动物基因组序列的可用性和对关键神经系统蛋白质功能的日益了解,我们才能够采取初步措施来描述构成神经系统的分子部分是如何形成的。我建议利用这些资源,开始开发一个模型,当和如何离子通道神经递质受体是中央的快速神经传递在所有后生动物进化。
英文摘要
Animal nervous systems are the most complex, computationally powerful objects in the known universe. To explain how that complexity arose as a result of changes at the molecular level is a major challenge for the theory of Darwinian evolution. Only recently, with the availability of multiple diverse metazoan genome sequences and a growing understanding of the function of key nervous system proteins, have we been able to take initial steps towards a description of how the molecular parts that make up the nervous system came to be. I propose to exploit these resources to begin to develop a model of when and how the ion channel neurotransmitter receptors that are central to fast neurotransmission in all metazoa evolved.
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Understanding drug resistance in multicellular parasites
  • 批准号:
    RGPIN-2017-04417
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.79万
  • 财政年份:
    2021
  • 负责人:
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  • 依托单位:
Understanding drug resistance in multicellular parasites
  • 批准号:
    RGPIN-2017-04417
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2020
  • 负责人:
    Dent, Joseph
  • 依托单位:
Understanding drug resistance in multicellular parasites
  • 批准号:
    RGPIN-2017-04417
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2019
  • 负责人:
    Dent, Joseph
  • 依托单位:
Understanding drug resistance in multicellular parasites
  • 批准号:
    RGPIN-2017-04417
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2018
  • 负责人:
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  • 依托单位:
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