Multi-modal calibration techniques for quantitative brain imaging

该研究计划旨在开发新的成像方法，以便更详细，更准确地测量大脑中不同的生理过程。 这些技术将涉及磁共振成像和新的光学成像方法的组合，其中高度穿透的低能量光通过头部投射。 这两种技术提供的数据可以通过使用脑组织的磁和光传播特性的新物理模型来整合，以产生对大脑输送和使用氧气的能力的更准确的测量。 这些测量将提供有关衰老和阿尔茨海默氏症等疾病和其他神经退行性疾病期间大脑功能变化的重要信息。

This research program aims to develop new imaging methods that allow more detailed and accurate measurements of different physiological processes in the brain. These techniques will involve a combination of magnetic resonance imaging and new optical imaging methods, where highly penetrating low energy light is projected through the head. The data provided by these two techniques can be integrated using new physical models of the magnetic and light propagation properties of brain tissue to produce more accurate measures of the brain's ability to deliver and use oxygen. Such measurements will provide important information on changes in brain function during aging and diseases such as Alzheimer's and other neurodegenerative conditions.