A multi-point sensor to measure pressures across vascular stenoses

本研究的目的是完成集成到血管造影导丝中的多点压力传感系统的开发和离体测试。该系统将作为一种诊断工具，用于辅助经皮冠状动脉介入治疗的决策，如球囊血管成形术和支架。该系统将由多个压力传感器组成，沿着单个血管造影导丝的长度部署。单个传感器将基于一种常见的光纤设备，即光纤内布拉格光栅。在临床应用中，患者将通过经皮股骨入路置管，导丝将放置，使传感器跨越目标狭窄。该系统将同时测量沿着狭窄区域长度的多个站点的动态压力，或者在连续病变的情况下，测量狭窄区域。因此，它将为医生提供比现有压力传感技术更详细和准确的关于狭窄程度的信息。这项工作完成后，该系统将适用于动物模型的体内测试。

The objective of the proposed research is to complete the development and ex vivo testing of a multi-point pressure sensing system integrated into an angiographic guidewire. This system will be used as a diagnostic tool to assist in therapeutic decisions for percutaneous coronary interventions such as balloon angioplasty and stents. The system will consist of multiple pressure sensors deployed along the length of a single angiographic guide wire. Individual sensors will be based on a common fibre-optic device, the in-fibre Bragg grating. In clinical use, patients will be catheterized by percutaneous femoral approach and the guide wire will be positioned such that the sensors span the target stenosis This system will simultaneously measure dynamic pressures at multiple stations along the length of a stenotic region or, in the case of serial lesions, stenotic regions. It will, therefore, provide physicians with much more detailed and accurate information about the severity of stenoses than existing pressure sensing technologies. Upon completion of this work, the system will be suitable for in vivo testing in an animal model.