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Phenylbutyrate use to target phosphorylation pathways in human disease

Phenylbutyrate use to target phosphorylation pathways in human disease
丁酸苯酯用于靶向人类疾病中的磷酸化途径
批准号：
248081
负责人：
Campeau Philippe M
金额：
$3.64万
依托单位：
Baylor College of Medicine (Texas)
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-10-01 至 2012-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=248081&lang=en
关键词：
Cell Signaling Diabetes Energy Metabolism Histone Deacetylases Osteoporosis Phosphoproteomics Unfolded Protein Response

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中文摘要
翻译
我们的目的是破译药物苯丁酸酯（PB）作用于身体的方式。铅被用于罕见的遗传性疾病尿素循环病，在这种疾病中，氨从蛋白质到尿素的转化受阻导致严重的疾病
英文摘要
We aim at deciphering the ways by which the drug phenylbutyrate (PB) acts on the body. PB is used in the rare genetic diseases known as Urea Cycle Diseases, in which a block in the transformation of ammonia from proteins to urea leads to significant disea
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