Insulin assay through high performance liquid chromatography

我的NSERC支持的研究方向是专注于胰岛素药物输送使用新的和新颖的封装方法和材料的方法。该研究围绕三个主要目标，通过胰岛素输送相互关联。第一个目标是实现从微粒，然后最终从嵌入天然聚合物泡沫或膜内的微粒长期（数天和数周）递送低水平胰岛素。长期目标是设计用于烧伤和创伤的生物活性敷料。第二个目的是将人胰岛细胞与制造的细胞基质蛋白一起封装在聚合物颗粒内。加拿大是胰岛移植疗法的领导者，这一举措可以通过增强植入胰岛的活力和葡萄糖反应性胰岛素的产生来促进糖尿病治疗的发展。第三个目标是对天然聚合物进行化学修饰，提供自然界中不存在或以前未合成的新型生物材料。其目的是将新的生物材料用于口服胰岛素递送和其他药物递送应用。

The direction of my NSERC supported research is to focus on insulin drug delivery using new and novel approaches in encapsulation methods and materials. The research is built around three main objectives, interrelated through insulin delivery. The first objective is to achieve long term (days and weeks) delivery of low levels of insulin from microparticles, then ultimately from microparticles embedded within natural polymer foams or films. The long-term goal is to design bioactive dressings for burn and wound injuries. The second objective is to encapsulate human islet cells together with fabricated cell matrix proteins within a polymeric particle. Canada is a leader in islet implantation therapies, and this initiative can contribute to the advancement of diabetes treatment through enhanced implanted islet viability and glucose-responsive insulin production. The third objective is to chemically modify natural polymers, providing novel biomaterials that do not exist in nature, or have not been previously synthesized. The intent is to use the new biomaterials for oral insulin delivery and other drug delivery applications.