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microRNA regulation of ABCA1 and its impact on beta cell function

microRNA regulation of ABCA1 and its impact on beta cell function
ABCA1 的 microRNA 调控及其对 β 细胞功能的影响
批准号：
252457
负责人：
Hayden Michael R
金额：
$40.74万
依托单位：
BC Children's Hospital Research Institute
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-03-01 至 2017-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=252457&lang=en
关键词：
Abca1 Beta Cells Cholesterol Diabetes Microrna Mouse Models

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中文摘要
翻译
2型糖尿病是疾病和死亡的主要原因，目前影响250万加拿大人。ABCA 1是从细胞中清除胆固醇的关键，从而防止其在细胞内积累。β细胞中缺乏ABCA 1导致胆固醇积聚
英文摘要
Type 2 diabetes is a major cause of disease and death, currently affecting 2.5 million Canadians. ABCA1 is crucial for removing cholesterol from cells thereby preventing its accumulation within cells. Lack of ABCA1 in beta cells leads to cholesterol accum
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Allele-specific lowering of mutant polyQ proteins as treatment for Huntington disease, spinocerebellar ataxia type 3 and spinocerebellar ataxia type 7
Novel Approaches Directed to Prevention and Treatment of Huntington Disease
Canada Research Chair Tier 1
  • 批准号：
    315426
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2014
  • 负责人：
    Hayden Michael R
  • 依托单位：
    University of British Columbia
Novel approaches to modulate key targets in the pathogenesis of Huntington Disease
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