Carbon nanotube bacterial cell interactions: development of carbon nanotube formulations for targeted destruction of pathogenic antibiotic resistant bacterial cells.

抗生素耐药病原菌是当今动物、人类和环境卫生领域的一个主要问题。这项研究计划涉及多功能碳纳米管(CNTs)配方的开发，其特定目标是有针对性地摧毁耐抗生素的致病细菌细胞。所解决的问题是由基础材料科学、化学和纳米技术研究以及生物医学技术发展的要求所激发和定义的。这项研究还解决了纳米材料细菌细胞相互作用的基本问题。纳米材料是一种强大的工业材料，用于化学、生物化学、医疗保健等行业的纳米技术研究迅速增长。然而，碳纳米管等纳米材料对环境、食物链和人类健康的暴露还没有完全了解。在这种情况下，碳纳米管最有可能首先与环境和胃肠道细菌细胞相互作用，这种相互作用需要进行详细的研究。该研究的目的是开展基础和应用研究，并研究碳纳米管与胃肠道细菌细胞的相互作用。这项研究将有助于理解纳米材料与细菌细胞相互作用的基本机制，并将有助于推进纳米材料对环境、动物和人类健康影响的基础知识。如果成功，这项研究将产生CNT疗法来对抗抗生素耐药性的致病细菌细胞。这项研究将为培养高素质的人才提供几个机会。

Antibiotic-resistant pathogenic bacteria are a major concern today, in the fields of animal, human and environmental health. This research program concerns with the development of multifunctional carbon nanotubes (CNTs) formulations with the specific aim of targeted destruction of antibiotic resistant pathogenic bacterial cells. The problems addressed are motivated and defined by requirements of the fundamental material science, chemistry and nanotechnology research and biomedical technology developments. The research also addresses the fundamental issues of nanomaterial bacterial cell interactions. Nanomaterials are powerful industrial materials and there has been rapid growth in nanotechnology research for use in chemical, biochemical, healthcare and other industries. However, environmental, food chain and human health exposures of the nanomaterials like CNTs are yet to be fully understood. In such an event the CNTs are most likely to interact first with environmental and GI bacterial cells and such an interaction warrants detailed investigation. The research aim is to perform fundamental and applied research and investigate carbon nanotube gastrointestinal bacterial cell interactions. This study will help understand the basic mechanisms of nanomaterial interactions with bacterial cells and will contribute to the advancement of fundamental knowledge of nanomaterial impacts on environmental, animal and human health. If successful, this research will result in CNT therapies to combat antibiotic resistance pathogenic bacterial cells. This research will provide several opportunities for training of highly qualified personal.