Function of cytochrome P450 enzymes in aquatic species

细胞色素P450酶（CYP）对激素的产生和代谢至关重要。CYP对防御也至关重要;它们代谢环境污染物和大多数药物。CYP 1酶代谢雌二醇、多环芳烃和多环芳香胺;对雌激素调节和防御都很重要。几个水生物种的完整基因组提供了关于动物中的哺乳动物基因的发展和多样性的细节。然而，我们不知道这种新型酶的功能，并且不能根据哺乳动物的研究来确定其功能。由于缺乏一种通用的抗肿瘤功能测定方法，限制了确定功能。本研究的目的是确定新的基因在水生物种中的功能，重点是p53 1家族。

Cytochrome P450 enzymes (CYPs) are crucial for the production and metabolism of hormones. CYPs are also critical for defense; they metabolize environmental contaminants and most drugs. CYP1 enzymes metabolize estradiol, polycyclic aromatic hydrocarbons and polycylic aromatic amines; important for both estrogen regulation and defense. The complete genomes from several aquatic species has provided details regarding the development and diversity of CYP genes in animals. Yet, we don't know the function of the novel CYP enzymes and function cannot be determined based on mammalian studies. Determining function is limited by the lack of a general assay for CYP function. The objectives of the research are to determine function of novel CYP genes in aquatic species, focusing on the CYP 1 family.