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Molecular mechanisms and function of AID-dependent antibody diversification

Molecular mechanisms and function of AID-dependent antibody diversification
AID依赖性抗体多样化的分子机制和功能
批准号：
265536
负责人：
Di Noia Javier M
金额：
$52.49万
依托单位：
Institut de recherches cliniques de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-09-01 至 2017-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=265536&lang=en
关键词：
Activation Induced Deaminase Antibody Gene Diversification Antibody Isotype Switching Antibody Mediated Immune Response Genetically Modified Mice Lymphocyte B Molecular Biology Protein Stability Subcellular Localization

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中文摘要
翻译
抗体是免疫系统的基本组成部分，因为它们可以识别和中和几乎任何病原体或毒素。我们需要能够产生足够大的抗体库来匹配几乎无限数量的抗原
英文摘要
Antibodies are fundamental components of the immune system because they can recognize and neutralize almost any pathogen or toxin. We need to be able to produce a sufficiently large repertoire of antibodies to match a virtually infinite number of antigens
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会议论文
Molecular mechanisms underlying high-affinity and isotype switched antibody responses
Regulation of germinal center B cell function during antibody responses
DNA deamination in adaptive and innate immunity: 20 years after the discovery of Activation induced deaminase
Regulation and impact of productive AID targeting during antibody responses.
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