Endocrine control of gestation in mammals: role of the novel steroid estradienolone (ED) in pregnancy

维持妊娠和分娩的细胞机制是复杂的，而且还不是很清楚。我们在孕妇体内发现了一种新的类固醇激素，我们将其命名为ED。ED的生物学特性表明，ED可能在维持妊娠中起重要作用。我们在目前的提案中的目标是了解这种荷尔蒙在怀孕期间的作用机制。和其他荷尔蒙一样，ED只在血液和尿液中少量存在。重要的是要用化学方法合成ED，这样大量的ED才能用于各种实验。ED的化学合成需要确定其精确的结构。我们建议研究ED如何影响胎儿、胎盘以及它如何参与控制妊娠。从这些研究中获得的知识可能会为减少动物和人类早孕损失和更好地管理怀孕的新发现开辟道路。

The cellular mechanisms involved in the maintenance of pregnancy and parturition are complex and not well understood. We have discovered a novel steroid hormone in pregnant women which we have named ED. The biological properties of ED indicate that ED may play an important role in pregnancy maintenance. Our goal in the current proposal is to understand the mechanism by which this hormone acts during pregnancy. Like other hormones, ED is present only in small quantities in blood and urine. It is important to chemically synthesize ED so that large amounts are available for a wide variety of experiments. The chemical synthesis of ED requires determining the precise structure of ED. We propose to study how ED affects the fetus, placenta and how it is involved in the control of pregnancy. Knowledge gained from these studies may open ways to new discoveries for reducing early pregnancy losses and better management of pregnancy in animals and humans.