Probing structure and causality in biochemical networks with dynamic homomeric protein complexes
Probing structure and causality in biochemical networks with dynamic homomeric protein complexes
批准号:
194582-2010
负责人:
Michnick, Stephen
金额:
$8.23万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-01-01 至 2014-12-31
中文摘要
问题与假设:蛋白质-蛋白质相互作用(PPI)对生物学的重要性反映在大规模研究它们的巨大努力中,包括我们自己的努力,这导致了体内PPI网络的首次描述(Tarassov,et al. Science,2008)。然而,像其他努力一样,我们在单一条件下捕获了蛋白质相互作用网络的静态图。 研究PPI网络的总体目标是了解蛋白质如何作为一个整体发挥作用。为了实现这一点,我们必须超越PPI的静态地图
英文摘要
Problem and Hypothesis: The importance of protein-protein interactions (PPIs) to biology is reflected in the colossal efforts to study them on a large scale, including our own efforts, which resulted in a first description of a PPI network in vivo (Tarassov, et al. Science, 2008). However, like other efforts, ours captured a static map of the protein interaction network under a single condition. The general goal of studying PPI networks is to understand how proteins function as an ensemble. To achieve this, we must go beyond static maps of PPI
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Dynamic protein interaction networks to map molecular origins of envronmental and genomic variations.
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批准号:RGPIN-2021-03216
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.23万
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财政年份:2022
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负责人:Michnick, Stephen
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依托单位:
Dynamic protein interaction networks to map molecular origins of envronmental and genomic variations.
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批准号:RGPIN-2021-03216
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.23万
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财政年份:2021
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依托单位:
Structure, dynamics and causality in protein interaction networks
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批准号:RGPIN-2015-05707
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2019
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负责人:Michnick, Stephen
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依托单位:
Structure, dynamics and causality in protein interaction networks
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批准号:RGPIN-2015-05707
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2018
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负责人:Michnick, Stephen
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依托单位:
Structure, dynamics and causality in protein interaction networks
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批准号:RGPIN-2015-05707
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2017
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负责人:Michnick, Stephen
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依托单位:
Structure, dynamics and causality in protein interaction networks
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批准号:RGPIN-2015-05707
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2016
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负责人:Michnick, Stephen
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依托单位:
Structure, dynamics and causality in protein interaction networks
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批准号:RGPIN-2015-05707
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2015
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负责人:Michnick, Stephen
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依托单位:
Probing structure and causality in biochemical networks with dynamic homomeric protein complexes
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批准号:194582-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$8.23万
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财政年份:2014
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负责人:Michnick, Stephen
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依托单位:
Probing structure and causality in biochemical networks with dynamic homomeric protein complexes
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批准号:194582-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$8.23万
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财政年份:2012
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负责人:Michnick, Stephen
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依托单位:
Probing structure and causality in biochemical networks with dynamic homomeric protein complexes
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批准号:194582-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$8.23万
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财政年份:2011
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负责人:Michnick, Stephen
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依托单位:
Probing structure and causality in biochemical networks with dynamic homomeric protein complexes
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批准号:194582-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$8.23万
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财政年份:2010
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负责人:Michnick, Stephen
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依托单位:
General approach to identifying protein fold and function signature sequences
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批准号:194582-2005
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.71万
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财政年份:2009
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负责人:Michnick, Stephen
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依托单位:
General approach to identifying protein fold and function signature sequences
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批准号:194582-2005
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.71万
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财政年份:2008
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负责人:Michnick, Stephen
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依托单位:
General approach to identifying protein fold and function signature sequences
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批准号:194582-2005
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.71万
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财政年份:2006
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负责人:Michnick, Stephen
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依托单位:
General approach to identifying protein fold and function signature sequences
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批准号:194582-2005
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.71万
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财政年份:2005
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负责人:Michnick, Stephen
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依托单位:
Identification of residues that participate in nucleation in fast-folding proteins
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批准号:194582-2000
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.82万
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财政年份:2003
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负责人:Michnick, Stephen
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依托单位:
Identification of residues that participate in nucleation in fast-folding proteins
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批准号:194582-2000
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.82万
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财政年份:2002
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负责人:Michnick, Stephen
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依托单位:
Identification of residues that participate in nucleation in fast-folding proteins
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批准号:194582-2000
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.82万
-
财政年份:2001
-
负责人:Michnick, Stephen
-
依托单位:
Identification of residues that participate in nucleation in fast-folding proteins
-
批准号:194582-2000
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.82万
-
财政年份:2000
-
负责人:Michnick, Stephen
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依托单位:
Identification of residues that participate in nucleation in fast-folding proteins
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批准号:194582-1999
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.91万
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财政年份:1999
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负责人:Michnick, Stephen
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依托单位:
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