Novel enantioselective routes to molecules posessing planar, helical and axial chirality

手性是分子的一种性质，对生物有着非凡的影响。 使用不对称催化来制备具有四面体手性的分子已经对制药工业产生了巨大的影响。 最近，已经发现具有手性的替代形式的分子对于药物化学同样有趣，并且具有可以在纳米科学、材料科学和催化中利用的有趣性质。 令人惊讶的是，开发新的对映选择性策略来获得这些分子仍然不发达。 目前的建议概述了新的合成技术的发展，以制备分子拥有平面，轴向或螺旋手性的元素。 具有这些类型手性的分子由于其固有的良好定义的不对称空间环境和有趣的光学性质而受到高度重视。 通过使用先进的合成方法如不对称催化来开发这些手性分子的新合成，我们可以获得新的生物活性分子和新的有机材料。

Chirality is a property of molecules that has an extraordinary impact on living beings. The use of asymmetric catalysis to prepare molecules having tetrahedral chirality has had an enormous impact on the pharmaceutical industry. Recently, molecules having alternative forms of chirality has been found to be equally as interesting for medicinal chemistry and possess interesting properties that can be exploited in nanoscience, materials science, and catalysis. Surprisingly, the development of new enantioselective strategies to access these molecules remains underdeveloped. The current proposal outlines the development of new synthetic technologies to prepare molecules possessing elements of planar, axial or helical chirality. Molecules possessing these types of chirality are highly valued due to their inherently well defined asymmetric steric environment and interesting optical properties. By developing new syntheses of these chiral molecules using advanced synthetic methods such as asymmetric catalysis, we can access new biologically active molecules and new organic materials.