The genetic basis of the long-term maintenance of muscle function in animals.

我研究的总体目标是了解组织是如何形成的，以及一旦它们形成，它们如何在生物体的整个生命过程中保持其组织。特别是我的实验室利用遗传方法来剖析各种机制，确保组织能够保持其结构，从而保持其在整个生命周期中发挥作用的能力。肌肉细胞在这方面特别有趣，因为它们在结构上高度组织化，并且寿命相对较长，这意味着它们长时间保持其结构完整性。这是值得注意的，因为肌肉承受巨大的机械负荷，因为经历放松和收缩的周期。我提议的NSERC资助的研究项目将调查肌肉细胞如何能够在持续的机械应力下在生物体的整个生命过程中保持其组织和功能。

The overall goal of my research is to understand how tissues form and once they form how they maintain their organization throughout the life of the organism. In particular my lab utilizes genetic approaches to dissect various mechanism ensure tissues are able to maintain their structure and thus their ability to function throughout life. Muscle cells are particularly interesting in this regard because they are both highly organized structurally and relatively long lived, meaning that they sustain their structural integrity for a long time. This is remarkable because muscle withstand enormous mechanical loads as the undergo cycles of relaxation and contraction. The NSERC funded research program I propose will investigate the how muscle cells are able to maintain their organization and function throughout the life of the organism while under sustained mechanical strain.