Regulating viral protein production and stability using small molecules

病毒是非常有选择性和高效的核酸递送装置，是研究复杂蛋白质组合和核心细胞功能的优秀模型系统。一些最复杂且知之甚少的病毒是疱疹病毒科的成员。在我们实验室研究的模型疱疹病毒-2型单纯疱疹病毒的情况下，病毒由大约100种不同的蛋白质组成。班菲尔德实验室的一个研究重点是了解这些迷人的结构组装的机制。

Viruses are remarkably selective and efficient nucleic acid delivery devices that serve as excellent model systems for studying complex protein assemblies as well as core cellular functions. Some of the most complicated and poorly understood viruses are the members of the Herpesviridae. In the case of the model herpesvirus studied in our laboratory, herpes simplex virus type 2, the viruses are built from about 100 different proteins. A focus of research in the Banfield laboratory is to understand the mechanisms by which these fascinating structures assemble.