Bioinformatics for comparative and evolutionary genomics

提出的研究项目侧重于基因组学计算方法的发展。这些方法解决的主要生物学问题围绕着作用于不同功能和非功能元素的进化过程之间的相互作用。我将特别关注同源基因家族和真核生物基因结构的进化。该项目旨在开发新的计算方法来研究剪接体内内含子的获得和损失，或基因的获得和损失。依靠系统发育背景下复杂的得失数学模型，这些方法有望揭示塑造现代基因组的选择力量，并有助于功能基因注释。

The proposed research project focuses on computational method development in genomics. The main biological questions adressed by the methods revolve around the interplay between evolutionary processes acting on different functional and non-functional elements. I will in particular focus on the evolution of homolog gene families and of eukaryotic gene structure. The project aims to develop novel computational methods to study the gain and loss of spliceosomal introns, or the gain and loss of genes. Relying on sophisticated mathematical models of gains and losses in a phylogenetic context, the methods are expected to shed light on selection forces that shaped modern genomes, and to aid in functional gene annotations.