Heart valve cell and matrix biomechanics and mechanobiology
Heart valve cell and matrix biomechanics and mechanobiology
批准号:
327627-2011
负责人:
Simmons, Craig
金额:
$2.33万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-01-01 至 2015-12-31
中文摘要
心脏瓣膜疾病是加拿大最常见的心脏病病因之一。目前,还没有治疗瓣膜疾病的药物。这是因为人们对引发和驱动这种疾病的细胞和分子知之甚少。重要的是,瓣膜在受到特定机械力的区域发生病变,这表明机械力导致这些区域的局部细胞从健康变为病变。为了研究这是如何发生的(从而有希望确定治疗目标),我们需要更深入地了解整个瓣膜水平的力是如何转移到瓣膜组织内的细胞以调节其功能的。
英文摘要
Diseases of the heart valves are among the most frequent causes of heart disease in Canada. Currently, there is no medicine available to treat valve disease. This is because little is known about the cells and molecules that initiate and drive the disease. Importantly, valves become diseased in regions subjected to specific mechanical forces, suggesting that mechanical forces cause the cells locally in these regions to change from healthy to diseased. In order to study how this occurs (and therefore hopefully identify therapeutic targets), we required a deeper understanding of how forces at the level of the whole valve get transferred to the cells within the valve tissue to regulate their function.
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会议论文
Integrated biosensors for organ-on-a-chip and physiological monitoring platforms
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批准号:RGPIN-2022-04375
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.66万
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财政年份:2022
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负责人:Simmons, Craig
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依托单位:
Melt electrowrite system for biofabrication of complex engineered tissues
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批准号:RTI-2023-00475
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项目类别:Research Tools and Instruments
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资助金额:$10.93万
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财政年份:2022
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负责人:Simmons, Craig
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依托单位:
Biosensing for organ-on-a-chip platforms
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批准号:RGPIN-2016-06026
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.86万
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财政年份:2021
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负责人:Simmons, Craig
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依托单位:
Biosensing for organ-on-a-chip platforms
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批准号:RGPIN-2016-06026
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.86万
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财政年份:2020
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负责人:Simmons, Craig
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依托单位:
A microfluidic blood-brain barrier model with on-chip cell barrier biosensing
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批准号:531083-2018
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项目类别:Collaborative Research and Development Grants
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资助金额:$6.78万
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财政年份:2019
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负责人:Simmons, Craig
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依托单位:
Biosensing for organ-on-a-chip platforms
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批准号:RGPIN-2016-06026
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.86万
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财政年份:2019
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负责人:Simmons, Craig
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依托单位:
Development of a physiological cardiac microtissue platform for drug development
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批准号:508366-2017
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项目类别:Collaborative Health Research Projects
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资助金额:$19.31万
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财政年份:2018
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负责人:Simmons, Craig
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依托单位:
Engineering Pulmonary Valve Tissue for Pediatric Patients with Tetralogy of Fallot
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批准号:508364-2017
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项目类别:Collaborative Health Research Projects
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资助金额:$18.79万
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财政年份:2018
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负责人:Simmons, Craig
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依托单位:
A microfluidic blood-brain barrier model with on-chip cell barrier biosensing**
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批准号:531083-2018
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项目类别:Collaborative Research and Development Grants
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资助金额:$6.78万
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财政年份:2018
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负责人:Simmons, Craig
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依托单位:
Biosensing for organ-on-a-chip platforms
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批准号:RGPIN-2016-06026
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.86万
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财政年份:2018
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负责人:Simmons, Craig
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依托单位:
Development of a physiological cardiac microtissue platform for drug development
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批准号:508366-2017
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项目类别:Collaborative Health Research Projects
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资助金额:$11.78万
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财政年份:2017
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负责人:Simmons, Craig
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依托单位:
Biosensing for organ-on-a-chip platforms
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批准号:RGPIN-2016-06026
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.86万
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财政年份:2017
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负责人:Simmons, Craig
-
依托单位:
Engineering Pulmonary Valve Tissue for Pediatric Patients with Tetralogy of Fallot
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批准号:508364-2017
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项目类别:Collaborative Health Research Projects
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资助金额:$9.39万
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财政年份:2017
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负责人:Simmons, Craig
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依托单位:
Biosensing for organ-on-a-chip platforms
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批准号:RGPIN-2016-06026
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.86万
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财政年份:2016
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负责人:Simmons, Craig
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依托单位:
Bioreactors for biomechanical conditioning and evaluation of native and engineered tissues
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批准号:RTI-2017-00141
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项目类别:Research Tools and Instruments
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资助金额:$10.93万
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财政年份:2016
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负责人:Simmons, Craig
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依托单位:
Development of a microfluidic 3D vascularized tissue model with integrated electric cell-layer impendance sensing
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批准号:478874-2015
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项目类别:Idea to Innovation
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资助金额:$9.11万
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财政年份:2015
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负责人:Simmons, Craig
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依托单位:
Advanced platform to characterize the mechanical and structural properties of natural and engineered soft biomaterials
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批准号:RTI-2016-00498
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项目类别:Research Tools and Instruments
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资助金额:$10.92万
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财政年份:2015
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负责人:Simmons, Craig
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依托单位:
Small animal echocardiographic particle-image velocimetry
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批准号:481657-2015
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2015
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负责人:Simmons, Craig
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依托单位:
Heart valve cell and matrix biomechanics and mechanobiology
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批准号:327627-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.33万
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财政年份:2015
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负责人:Simmons, Craig
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依托单位:
Biomaterial substrates for xeno- and feeder layer-free culture of human pluripotent stem cells
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批准号:478473-2015
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项目类别:Collaborative Health Research Projects
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资助金额:$8.55万
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财政年份:2015
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负责人:Simmons, Craig
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依托单位:
海外基金