Multi-modal calibration techniques for quantitative brain imaging

该研究项目旨在开发新的成像方法，以便对大脑中不同的生理过程进行更详细和准确的测量。这些技术将包括磁共振成像和新的光学成像方法的结合，其中高穿透性的低能量光通过头部投射。这两种技术提供的数据可以与大脑组织的磁性和光传播特性的新物理模型相结合，从而更准确地测量大脑输送和使用氧气的能力。这样的测量将提供关于衰老过程中大脑功能变化的重要信息，以及老年痴呆症和其他神经退行性疾病。

This research program aims to develop new imaging methods that allow more detailed and accurate measurements of different physiological processes in the brain. These techniques will involve a combination of magnetic resonance imaging and new optical imaging methods, where highly penetrating low energy light is projected through the head. The data provided by these two techniques can be integrated using new physical models of the magnetic and light propagation properties of brain tissue to produce more accurate measures of the brain's ability to deliver and use oxygen. Such measurements will provide important information on changes in brain function during aging and diseases such as Alzheimer's and other neurodegenerative conditions.