Variable Mode Laser Scanner for Precise Imaging and Quantitation of Biomolecules

农业基因组学和蛋白质组学股农业，食品和营养科学系的AGP单元是一个多用户核心设施，支持来自牲畜Gentec集团，猪繁殖发展计划，阿尔伯塔创新植物中心，油菜育种计划，家禽研究小组，免疫学，食品微生物学，功能食品和营养品集团，以及加拿大农业和农业食品部的合作科学家。研究内容涉及多种主题，例如：与动物健康相关的肉牛和奶牛肠道微生物菌群的作用，基因组学在家畜中与肉质和健康相关性状的应用（猪和牛）;猪胎儿发育过程中的表观遗传调控;家畜物种中免疫相关基因变化的饮食和表观遗传影响;了解宿主-微生物相互作用的分子机制;油菜和小麦育种的标记发现;生产高附加值种子油的种子油形成的遗传调控;植物对非生物胁迫反应的分子机制和营养基因组学的微生物学。创新的努力应用于提高牲畜的繁殖性能，开发具有改善营养质量的动物产品，并创造具有改善抗病性和增值特性的作物。所有这些申请人都需要一种扫描仪，用于通过对多荧光、化学荧光和放射性同位素标记的样品进行成像来精确定量蛋白质、核酸和其他生物分子。该基础设施支持的研究将对加拿大农业未来的可持续性和盈利能力以及培养高素质人才发挥重要作用。

Agricultural Genomics and Proteomics Unit (AGP Unit) in the Department of Agricultural, Food and Nutritional Science is a multi-user core facility supporting the research programs of over 100 users from The Livestock Gentec Group, The Swine Reproduction-Development Program, Alberta Innovates Phytola Centre, Canola Breeding Program, Poultry Research Group, Immunology, Food microbiology, Functional Foods and Nutraceuticals group, and collaborating scientists at Agriculture and Agri-Food Canada. Research is conducted on diverse topics such as: the role of gut microflora in beef and dairy cattle related to animal health, the application of genomics in livestock for traits related to meat quality and health (swine and cattle); epigenetic regulation during fetal development in porcine; dietic and epigenetic influences on changes in immune related genes in livestock species; understanding molecular mechanisms of host-microbial interactions; marker based discovery for canola and wheat breeding; genetic regulation of seed oil formation for producing value-added seed oils; molecular mechanism of plant responses to abiotic stress and microbiology of nutrigenomics. Innovative efforts are applied to improve reproductive performance of livestock, developing animal products with improved nutritional qualities, and creating crops with improved disease resistance and value added characteristics. All these applicants require a scanner for precise quantitation of proteins, nucleic acids, and other biomolecules through imaging of multifluorescent-, chemifluorescent-, and radioisotope-labeled samples. The research supported by this infrastructure will play an important role towards the future sustainability and profitability of Canadian agriculture industries, and training highly qualified personnel.