Toward new solid-supported reagents

异氰酸酯是重要的大宗和精细化学品，广泛应用于化学工业。例如，它们是油漆和涂料的成分，用于创建耐候表面。它们还用于制造建筑材料（例如，聚苯乙烯泡沫塑料，软泡沫塑料，粘合剂，弹性体和粘合剂）和生产制成品（例如，床上用品，家具，服装，电器，电子产品，轮胎和包装）。全球异氰酸酯市场是巨大的-根据Markets and Markets的一项研究，“异氰酸酯市场预计将在未来五年内以健康的速度增长，达到387.29亿美元/年”。从产量和经济角度来看，具有两个异氰酸酯基团的化合物（二异氰酸酯）是最重要的。然而，异氰酸酯也是用于先进化学品制造的有价值的试剂（例如，作为用于生产药品和农用化学品的“结构单元”）。迄今为止，异氰酸酯的所有工业应用都涉及碳取代的异氰酸酯。 该提案旨在联合收割机将Beauchemin在新型异氰酸酯（氮取代异氰酸酯）方面的专业知识与SiliCycle在固体支撑试剂方面的专业知识相结合。SiliCycle是这一固定化试剂市场的国际先驱，该市场被制药行业用于在药品生产过程中去除痕量的有毒金属，遗传毒性杂质和其他有机污染物。固载试剂的优点是可以与它们发生化学反应，并且可以在简单过滤溶液后去除杂质。然而，目前的固载试剂具有局限性，并且鉴于监管机构如FDA和加拿大卫生部施加的严格要求，性能至关重要。新型固定化试剂将通过Beauchemin的N-取代异氰酸酯前体与SiliCycle负载树脂反应而快速合成。新树脂将

Isocyanates are important bulk and fine chemicals broadly used by the chemical industry. For examples, they are components of paints and coatings to create weather-resistant surfaces. They are also used to make building materials (for example, Styrofoam, flexible foams, adhesives, elastomers, and binders) and in the production of manufactured goods (for example, bedding, furniture, clothing, appliances, electronics, tires, and packaging). The global market for isocyanates is enormous - according to a study by Markets and Markets, "the isocyanate market is expected to grow with a healthy pace over the next five years to reach $38,729 million/year". From a volume and economic perspective, compounds with two isocyanates groups (di-isocyanates) are the most important. However, isocyanates are also valuable reagents used in advanced chemical manufacturing (for example as "building blocks" used to produce pharmaceuticals and agrochemicals). To date, all industrial applications of isocyanates relate to carbon-substituted isocyanates. This proposal aims to combine the expertise of Beauchemin on a new family of isocyanates (nitrogen-substituted isocyanates) with the expertise of SiliCycle on solid-supported reagents. SiliCycle is an international pioneer in this market of immobilized reagents, which are used by the pharmaceutical industry to remove trace levels of toxic metals, genotoxic impurities, and other organic contaminents during production of pharmaceuticals. The advantage of solid-supported reagents is that a chemical reaction can occur with them, and removal of impurities can occur upon simple filtration of the solution. However, current solid-supported reagents have limitations, and performance is critical given the stringent requirements imposed by regulatory agencies such as the FDA and Health Canada. New immobilized reagents will be rapidly synthesized by reacting Beauchemin's N-substituted isocyanate precursors with SiliCycle supported resins. The new resins will