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Generational and sex-specific effects of paternal environmental exposures on offspring development health

Generational and sex-specific effects of paternal environmental exposures on offspring development health
父亲环境暴露对后代发育健康的代际和性别特异性影响
批准号:
338527
负责人:
Kimmins Sarah
金额:
$109.28万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-11-01 至 2020-11-01

项目摘要

项目成果

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中文摘要
翻译
环境暴露的记忆如何从父母传给孩子,甚至传给曾孙,从而改变疾病的易感性,这在很大程度上是未知的。这种现象被称为表观遗传,与生化修饰有关
英文摘要
How memory of environmental exposures is transmitted from parents to children and even to great grandchildren to alter disease susceptibility is largely unknown. This pheneomena, known as epigenetic inheritance has been associated to biochemical modificat
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会议论文
Identifying molecular mechanisms underlying the regulatory role of sperm chromatin in embryo development and adult disease
  • 批准号:
    451944
  • 项目类别:
    Operating Grants
  • 资助金额:
    $67.15万
  • 财政年份:
    2021
  • 负责人:
    Kimmins Sarah
  • 依托单位:
Identification of functional epigenomic regions in sperm that are environmentally responsive and associate with fertility and embryo development
  • 批准号:
    451908
  • 项目类别:
    Operating Grants
  • 资助金额:
    $64.09万
  • 财政年份:
    2021
  • 负责人:
    Kimmins Sarah
  • 依托单位:
Canada Research Chair - Tier 1
  • 批准号:
    454009
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2021
  • 负责人:
    Kimmins Sarah
  • 依托单位:
Obesity and nutritional programming of the paternal sperm epigenome: effects on offspring development and health
  • 批准号:
    321141
  • 项目类别:
    Operating Grants
  • 资助金额:
    $78.47万
  • 财政年份:
    2015
  • 负责人:
    Kimmins Sarah
  • 依托单位:
海外基金