Synthesis of Novel Indole-Based Heterocycles

创造性的有机合成是喂养 众多研究领域的需求(如药品、农用化学品、 材料科学、催化、光化学、香料和颜料) 具有有趣的性质和拓扑的新型分子骨架是 不断地寻找。对于合成化学家来说，开发和开发 微调反应方法，实现高效绿色合成 想要的骨架。吲哚核在许多情况下是一种普遍的亚结构 天然产物和生物活性化合物。由于它的生物学特性 重要性，吲哚类化合物作为一种建筑引起了特别的关注 药物化学家开发治疗剂的障碍。一个 围绕吲哚核心的过多的生物活动继续是驱动力。 在开发新的方法以发现有用的化合物和 增加杂环的多样性。由此可见，高效发展的必要性 以及具有多种取代模式的吲哚的实用合成 具有重要的意义。我的研究计划的目的是探索 开发新的、高效的吲哚杂环合成方法 具有多种替换模式的。长期目标是使用 开发了丰富吲哚核周围杂环多样性的方法学 去寻找商业上有用的化学物质。

Creative organic synthesis is a cornerstone for feeding the demands of numerous research areas (such as pharmaceuticals, agrochemicals, material sciences, catalysis, photochemistry, fragrances and pigments) where novel molecular frameworks with interesting properties and topology are constantly sought. It is crucial for synthetic chemists to develop and fine-tune reaction methodologies that enable efficient and green synthesis of the desired skeletons. The indole core is a prevalent substructure in many natural products and biologically active compounds. Due to its biological importance, indole based compounds attract special attention as a building block for the development of therapeutic agents by medicinal chemists. A plethora of bioactivities surrounding the indole-core continue to be a driving force in the development of new methodology to find useful compounds and increase the heterocyle diversity. Thus, the need for development of efficient and practical syntheses of indoles bearing a variety of substitution patterns is of great significance. The objective of my research program is to explore and develop novel and efficient synthetic methodology of indole heterocycles bearing a variety of substitution patterns. The long-term goal is to use the developed methodology to enrich the heterocycle diversity around indole nucleus to find commercially useful chemicals.