Programmable High-Frequency Ultrasound Platform for Translational Biomedical Research

新的可编程超声阵列系统要求具有高频能力、高强度治疗输出能力、超快采集速度(&gt；5000帧/秒)、任意波形能力和完全可编程性。该系统将是我们在生物医学光声和超声成像领域多学科工作的关键仪器。它将用于连接新型2D微机械阵列换能器，实现高频光声和超声分子成像，实现新型超声辅助生物标记物释放和超声药物输送实验，实现新型近正交编码并行快速成像方案，实现新型超声散射张量成像和声束成像，以及将新型光声功能成像方法移植到临床。这些项目涉及艾伯塔大学和其他机构的一系列临床和基础科学合作者。该系统目前将支持24名以上受训人员的工作和协作项目，未来可能会有更多的用户。与大多数其他超声平台不同，所要求的系统具有新颖的每通道任意波形能力、深度存储器、快速流能力、高频能力、高输出能力和完全可编程能力，据我们所知，这将是加拿大第一个此类平台。虽然校园里存在其他超声平台，但没有一个平台配备了拟议的能力，阻碍了大量有前途的项目。

A novel programmable ultrasound array system is requested with high-frequency capabilities, high-intensity therapeutic output capabilities, ultrafast acquisition speeds (>5000 frames/sec), arbitrary waveform capabilities, and full programmability. The system will be a key piece of instrumentation for our multidisciplinary work in biomedical photoacoustic & ultrasound imaging. It will be used to interface to novel 2D micromachined array transducers, to enable high-frequency photoacoustic- and ultrasound molecular imaging, to permit novel ultrasound-aided biomarker release and ultrasound drug-delivery experiments, to enable novel near-orthogonal coded parallel fast imaging schemes, to enable novel ultrasound scattering-tensor imaging and tractography, and to migrate novel photoacosutic functional imaging methods to the clinic. These projects involve a wide array of clinical and basic science collaborators at the University of Alberta and other institutions. The system will support the work and collaborative projects of over 24 trainees presently, with potentially many more users in the future. The system requested has novel per-channel arbitrary-waveform capabilities, deep memory, fast-streaming capabilities, high-frequency capabilities, high-output capabilities, and full programmability, unlike most other ultrasound platforms and would be the first of it's kind in Canada to our knowledge. While other ultrasound platforms exist on campus, none of them are equipped with the proposed capabilities, hampering a large number of promising projects.