Dedicated Computational Infrastructure for Assembly and Analysis of Complex Genomes in Non-Model Organisms

下一代测序(NGS)技术的快速发展正在给生命科学带来革命性的变化，为从人类到非模式生物的各种分类群中探索基因组的结构和功能提供了新的机会。随着生物学家努力管理和分析日益增长的基因数据流，NGS技术的快速发展创造了一种尴尬的财富。例如，Illumina最新的HiSeq 4000平台每72小时可以对25亿个DNA片段(1.5万亿个碱基对)进行测序--而且这个产量每隔几年就会翻一番。因此，生物学家越来越依赖高性能计算来分析NGS数据，这导致了长队列和长运行时间导致的长时间延迟。

Rapid development of next-generation sequencing (NGS) technology is revolutionizing the life sciences, offering new opportunities to explore the structure and function of genomes in a diverse array of taxa from humans to non-model organisms. The rapid development of NGS technology has created an embarrassment of riches as biologists struggle to manage and analyze the growing streams of genetic data. For example, Illumina’s latest HiSeq 4000 platform can sequence 2.5 billion DNA fragments (>1.5 trillion base pairs), every 72 hours – and this output is doubling every few years. As a result, biologists are increasingly dependent on high-performance computing for the analysis of NGS data, leading to long delays as a result of long queues and long runtimes.