Endocrine control of gestation in mammals: role of the novel steroid estradienolone (ED) in pregnancy

参与维持妊娠和分娩的细胞机制是复杂的，尚未完全了解。我们在孕妇中发现了一种新的类固醇激素，我们将其命名为ED。艾德的生物学特性表明，艾德可能在妊娠维持中起重要作用。我们当前提案的目标是了解这种激素在怀孕期间的作用机制。像其他激素一样，艾德仅少量存在于血液和尿液中。重要的是化学合成艾德，以便大量可用于各种各样的实验。艾德的化学合成需要确定ED的精确结构。我们建议研究艾德如何影响胎儿、胎盘以及它如何参与妊娠的控制。从这些研究中获得的知识可能会为减少动物和人类早期妊娠损失和更好地管理妊娠开辟新的发现。

The cellular mechanisms involved in the maintenance of pregnancy and parturition are complex and not well understood. We have discovered a novel steroid hormone in pregnant women which we have named ED. The biological properties of ED indicate that ED may play an important role in pregnancy maintenance. Our goal in the current proposal is to understand the mechanism by which this hormone acts during pregnancy. Like other hormones, ED is present only in small quantities in blood and urine. It is important to chemically synthesize ED so that large amounts are available for a wide variety of experiments. The chemical synthesis of ED requires determining the precise structure of ED. We propose to study how ED affects the fetus, placenta and how it is involved in the control of pregnancy. Knowledge gained from these studies may open ways to new discoveries for reducing early pregnancy losses and better management of pregnancy in animals and humans.