Effects of diet on metabolic programming of glucose homeostasis

我的NSERC资助的研究计划的长期目标是了解在生长和发育的敏感时期营养摄入对身体在整个生命周期的不同时间控制血糖过程的影响。我的工作基于一个名为“健康和疾病的发展起源”（DOHAD）的实验范式，并专注于在整个生命周期的生长和发育的敏感时期饮食果糖（FR）摄入量的代谢影响;控制脂肪组织沉积在我的工作中很重要。工作假设是，在这些期间暴露于FR会对协调血糖控制的代谢系统产生负面影响。我研究饮食FR，因为它是已知的诱导胰岛素抵抗和高循环水平的胰岛素，因为它是相关的，在今天的社会。加拿大人每天消耗的总热量的21%来自糖，其中约50-60克是FR。超过35%的糖消耗来自添加糖（即在准备，加工或餐桌上添加）。我选择研究FR在妊娠期的影响，因为妊娠期和哺乳期是已知的生长发育最敏感的时期，并且糖的摄入量在妊娠期间增加。

The long-term objective of my NSERC-funded research program is to understand the impact of nutritional intake during sensitive periods of growth and development on processes in the body controlling blood glucose at different times across the lifespan. My work is grounded in an experimental paradigm called the "Developmental Origins of Health and Disease" (DOHAD) and focuses on the metabolic effects of dietary fructose (FR) intake during sensitive periods of growth and development across the lifespan; control of adipose tissue deposition is important in my work. The working hypothesis is that exposure to FR during these periods negatively affects the metabolic systems that coordinate the control of blood glucose. I study dietary FR because it is known to induce insulin resistance and high circulating levels of insulin, and because it is relevant in today's society. Canadians consume ~21% of their total daily calories from sugars, of which ~50-60 g is FR. More than 35% of sugar consumed is from added sugars (i.e. added during preparation, processing or at the table). I chose to study the effects of FR in pregnancy because gestation and lactation are the most sensitive periods of growth development known, and sugar intake increases during pregnancy.