The copolymerization of carbon dioxide and aziridine for the preparation of aliphatic polyurethanes

尽管医院和诊所的消毒程序越来越多，应用也越来越广泛，但医疗器械和植入物仍然是每年数百万医院获得性细菌感染的原因。因此，近年来，自杀菌材料的发展得到了增长。与医院细菌感染相关的危险由于“超级细菌”的增加而变得更加复杂，这些细菌已经对我们现有的许多抗菌剂产生了耐药性。在过去的25年中，恶唑烷酮已成为抗生素领域最伟大和最有前途的新发展之一。本提案强调了一种制备一类具有降解成恶唑烷酮抗菌分子能力的聚氨酯材料的方法。该提案侧重于聚合方法和所产生的新材料的表征。此外，该过程还包括将二氧化碳作为分子构建块纳入聚合物框架。利用废弃二氧化碳作为碳源制备材料的能力在环境可持续化学实践的发展中是非常令人兴奋的，并且对我们应对全球变暖的能力具有巨大的影响。

Despite the growth and application of sterilization procedures at hospitals and medical clinics, medical devices and implants are still the cause of millions of hospital-acquired bacterial infections each year. As such, the development of self-sterilizing materials has grown in recent years. The dangers associated with hospital-based bacterial infections are compounded by the increased occurrence of "super bugs", bacteria that have developed a resistance to many of our established antibacterial agents. In the past 25 years, oxazolidinones have emerged as one of the greatest and most promising new developments in the area of antibiotics. This proposal highlights a method to prepared a class of polyurethane materials that have the ability to degrade into oxazolidinone antibacterial molecules. The proposal focuses on the polymerization method and characterization of the resulting novel materials. In addition, the process also involves the incorporation of carbon dioxide as a molecular building block into the polymers framework. The ability to use waste carbon dioxide as a source of C in the preparation of materials is extremely exciting in the development of environmentally sustainable chemistry practices and has tremendous implications for our abilities to address global warming.