Design of new Asymmetric, Ion Pairing Catalysis and Reactions

拟议的研究计划 专注于不对称催化过程的发展， 手性有机化合物的研究。手性化合物在生物化学中起着重要的作用， 制药和农用化学工业。这些分子可以以 镜像（称为对映体）是所有生命的基石。是 已经确定化合物的对映异构体可以具有极大不同的对映异构体。 生物活动。有机化学的发展一直是一个挑战 强大而可靠的不对称催化过程， 手性化合物的单一对映体。非对称离子对场 催化是一种非常有前途和通用的方法， 产生广泛的复杂手性分子。虽然发展 在这一领域的催化已经迅速，急于开发的潜力， 这些方法在创新和理解之间留下了空白。深入 要想扩大这些催化剂的规模，就必须了解这些催化剂的机理 可以用这种不对称催化方法进行的反应。 拟议 发现性研究将提供对这些机制的基本见解， 这些不对称催化剂在产生手性化合物的单一对映体中的应用 分子。拟议的研究将扩大我们的武器库的对映选择性 反应，并导致普遍适用的发展，工业 相关催化方法 这将允许形成以前无法实现的复杂手性 分子。学生 参与这项研究计划将发展技能的动力学和计算 探索化学反应机理，学习高级合成， 这些特征化技术将使它们成为备受追捧的 因为他们的广泛技能。

The proposed research program focuses on the development of asymmetric catalytic processes for the production of chiral organic chemicals. Chiral compounds play an important role in pharmaceutical and agrochemical industries. These molecules, which can exist as mirror images (called enantiomers), are the building blocks of all life. It is well established that the enantiomers of a compound can have vastly different biological activities. It is a continuous challenge in organic chemistry to develop robust and reliable asymmetric catalytic process that allow for the formation of single enantiomers of chiral compounds. The field of Asymmetric, Ion Pairing Catalysis represents an extremely promising and versatile approach for generating a wide range of complex chiral molecules. While development in this area of catalysis has been rapid, the rush to exploit the potential of these methods has left a void between innovation and understanding. An in-depth knowledge of the mechanisms of these catalysts is required to expand the arsenal of reactions that can be performed with this asymmetric catalytic method. The proposed discovery research will provide fundamental insight into the mechanisms of these asymmetric catalysts in generating single enantiomers of chiral molecules. The proposed research will expand our arsenal of enantioselective reactions, and lead the development of generally applicable, industrially relevant catalytic methods that will allow for the formation of previously unachievable complex chiral molecules. Students involved in this research program will develop skills in kinetic and computational chemistry for exploring reactions mechanism and learn advanced synthesis and characterization techniques that together will make them highly sought after for their broad skill set.