Operations and Maintenance Support: Proteomic Resource Center

蛋白质组资源中心(PRC)为加拿大科学家提供生物质谱仪，重点是安大略省东部和魁北克省。PRC的重点是定量蛋白质组学(大规模蛋白质分析)、定量脂质组学(大规模脂类分析)、定量元蛋白质组学(大规模分析细菌群落中的蛋白质)和生物信息学。中国向科学界提供的技术在加拿大和世界上都是独一无二的。在过去五年中，进入中国的申请增加了两倍。中国带头开展了一项国际努力，以加强对不同质谱计的使用。特别是，它建立了加拿大(渥太华大学和拉瓦尔大学)和中国(上海和大连)的设施网络，大大提高了质谱仪的类型和数量，以及科学界可用的技术。这种接入模式是中国独有的。中国目前支持来自加拿大和国际科学家的60多个科学项目。中国支持的项目类型广泛，包括：技术开发、了解酵母和斑马鱼等模式生物的基本生物学过程，以及与阿尔茨海默氏症、帕金森病和儿童炎症性肠病等人类疾病相关的应用项目。中华人民共和国在生物质谱学和生物信息学方面提供广泛的培训。来自中国的预期成果是：训练有素的年轻科学家，可以商业化的技术，更好地了解对人类健康重要的基本过程，以及直接适用于临床的工具，如生物标记物。

The Proteomic Resource Center (PRC) provides access to biological mass spectrometry to Canadian scientists with a focus on Eastern Ontario and Quebec. The PRC focuses on quantitive proteomics (large scale analysis of proteins), quantitive lipidomics (large scale analysis of lipids), quantitive metaproteomics (large scale analysis of proteins from bacterial communities) and bioinformatics. The PRC offers technologies to the scientific community that are unique in Canada and some in the world. Requests for access to the PRC have grown two fold in the last five years. The PRC has spearheaded an international effort to enhance access to different mass spectrometers. In particular, it has created a network of facilities from Canada (University of Ottawa and Université Laval) and China (Shanghai and Dalian) greatly enhancing the type and quantity of mass spectrometers, as well as technologies available to the scientific community. This model of access is unique to the PRC. The PRC currently supports over 60 scientific projects from Canadian and international scientists. The types of projects supported by the PRC are broad including: technology development, understanding fundamental biological processes in model organisms such as yeast and zebrafish, and applied projects related to human diseases such as Alzheimer’s Disease, Parkinson Disease, and Inflammatory Bowel Disease in children. The PRC provides extensive training in biological mass spectrometry and bioinformatics. The anticipated outcomes from the PRC are: well-trained young scientists, technologies that can be commercialized, better understanding of fundamental processes important for human health, and tools such as biomarkers, that are directly applicable in the clinic.